New role for Spinophilin in tumor suppression.

www.landesbioscience.com Cell Cycle 3427 The molecular details of how lamin A influences 53BP1 stability and inhibits formation of p130/e2F4 repressor complexes remain to be identified. Lamins may directly bind to and affect these proteins, or these effects may be indirect. Altogether, the study by Redwood et al. provides a glimpse of novel functions of lamin A in both the transcription and stabilization of DnA damage repair components. Lamin A thus seems to also be involved in regulating the intricate cross talk between the different DsB repair pathways. References 1. stracker TH, et al. nat Rev Mol Cell Biol 2011; 12:90-103. 2. Dechat T, et al. Cold spring Harb symp Quant Biol 2010; 75:533-43. 3. Dechat T, et al. Genes Dev 2008; 22:832-53. 4. Liu y, et al. J Cell sci 2006; 119:4644-9. 5. Manju K, et al. J Cell sci 2006; 119:2704-14. 6. varela i, et al. nature 2005; 437:564-8. 7. Gonzalez-suarez i, et al. eMBO J 2009; 28:2414-27. 8. Dimitrova n, et al. nature 2008; 456:524-8. 9. Redwood AB, et al. Cell Cycle 2011; 10:2550-6.